CBD popularity can is on the rise, and it's in part due to the nature of CBD but also to the range of consumption methods available. Edibles and tinctures can have less of the stigma traditionally associated with joints. However, when cannabinoids such as CBD and THC enter your stomach in oil form, bioavailability becomes compromised. Here's our guide on getting the most out of your CBD products.
CBD, like THC oils, resist absorption into the bloodstream because the human body is up to 60% water. If you've read our article on making CBD-infused seltzer, you know just how challenging mixing oil and water are. It's just basic science.
That same concept can be analogous to the way cannabinoids work in the body.
CBD and its family of compounds are fat-loving molecules and have to in aqueous cellular pathways. Which makes sense when you consider just how much of the human body is made up of water.
So the idea is that when cannabis is consumed as an oil, the onset of effects can become delayed and bioavailability limited.
This is contrary to the idea that the oil, often coconut oil being the medium, is the correct dosing method.
Proper Dosing With CBD Oil
Dosage is the critical factor in achieving the most benefits and least adverse effects of cannabis. Due to bioavailability, these are the measurements recommended:
A mouth spray might contain 2.7 milligrams of THC and 2.5 milligrams of CBD at doses of 2.5-120 milligrams for up to eight weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24 hours.
CannLabs, the nation's top full-service testing lab for cannabis products, has determined that there is no established lethal CBD dose. Consumers should read product inserts carefully to ensure they are taking the right amount of CBD, and talk to their prescribing physician about any questions or concerns.
The First-Pass Effect
The first-pass effect is what limits oil-based cannabis extracts from reaching the bloodstream in large quantities. Orally, CBD is absorbed in the gastrointestinal tract and transported via the portal vein to the liver, where metabolized and made of use to the body.
Since cannabis oil is often taken orally, its efficacy can be hindered.
Are some cannabinoids more bioavailable than others?
Investigations into CBD have shown that the bioavailability of cannabinoids depends on the method of delivery. For instance, when targeting muscular systems and related body care, one should use a topical solution.
When applied as a topical ointment or transdermal patch, CBD can penetrate the tissue ten times more effectively than THC. Thus, muscle creams are more effective as a whole; however, they can only reach a certain depth of the skin, which we have outlined in our recent article.
How to Optimize Bioavailability?
Since the CBD market explosion, a slew of products has rushed onto the market. However, they might be the culprit in limiting bioavailability.
This is all due to how they "first pass" through the liver. With oral CBD, absorption can be slow, unpredictable, and highly variable.
Despite the speed of absorption, oral administration lasts longer than smoking, eliminating the need for frequent dosing. Oral and topical methods also avoid irritation to the airways and the risk of malignancies associated with smoking or vaping.
By following dosage guidelines and understanding limited bioavailability via consumption methods, we hope that you can make the most of all your CBD products.